The BRAoVO panel looks at high and moderate high risk genes associated with an increased lifetime risk of breast and ovarian cancers, as well as other cancers such as prostate and pancreatic cancer.
The panel contains 13 genes – ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, PALB2, PTEN, RAD51C, RAD51D, STK11 and TP53.
BRCA1 and BRCA2 are the most commonly involved and can also be tested for as a 2-gene panel only.
We now also have the BRAoVO Plus panel, which looks at all those genes covered in the BraOVO panel, along with 5 additional genes: MLH1, MSH2, MSH6, PMS2 & EPCAM.
These are important for breast cancer patients with a family history that includes ovarian cancer and is also useful for families where there is a mixed cancer picture of breast +/- ovarian +/- colorectal cancer.
Familial cancer gene testing looks at only a single gene, performed when a biological relative has been shown to have this gene.